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What is Benfotiamine?
Often people suffer from diabetes and serious pain. Diabetic patients suffer from various serious health-related issues. The issues might be long term or short term. Diabetics affect the patient’s eyes, kidney, brain, and many active body organs. In order to be safe from diabetics, the patients need to control their blood sugar level and Benfotiamine is the best available option for them. The diabetic patients need to maintain a normal blood sugar level and it helps to keep to sugar level balanced. As diabetes brings several adverse effects on the human body, it is highly recommended to the diabetic patients to maintain their blood sugar level. This is only possible if they take a limited dosage of Benfotiamine.
If somebody has got diabetes, then it’s a serious health issue which the individual must take seriously. As the complete cure for diabetes is really challenging, it’s a must that the patients take this disease seriously. It is directly linked to several health problems. But, this is not the end as there are some ways by following which the diabetic patients can actually reduce their health risks from diabetics.
The first step to lower diabetic risk is to control the patient’s blood sugar level at a normal level. If the sugar level can be maintained properly, then the patient will have lower health risks. This product can help the diabetic patients to balance their blood sugar level to normal. By having a limited dosage of Benfotiamine, the diabetic patients can maintain a normal blood sugar level easily.
It is a relatively fat-soluble form of the vitamin Thiamine or vitamin B-1. It is very effective to lower blood sugar level to normal and reduces severe pain. Several diabetic complications, including the nephropathies and neuropathies, can be effectively reduced by using the proper dosage of Benfotiamine.
It contains bioavailable vitamin B-1 which plays a therapeutic role to maintain normal blood sugar levels of diabetic patients. Benfotiamine is one fat and lipid soluble and that is why the human body is capable of metabolizing Benfotiamine easily and quickly after intact. So, after having this product it shows its effect quickly and effectively. The reason behind this is that vitamin B-1 is easily absorbed by the human body.
Why is Thiamine important for the human body?
Thiamine is the other name of vitamin B-1 which enables the human body to use the carbohydrates as a source of energy. Thiamine is essential for every human body for the glucose metabolism process. Thiamine plays an important role to make the heart, human nervous system and muscles function properly. Indeed Thiamine is water soluble and every human body required a limited amount of Thiamine on a regular basis to maintain proper body functions.
As Thiamine is not stored in the human body for future use, people must intake Thiamine on a regular basis. Sometimes, people do include Thiamine rich foods in their daily diet, but still, the body suffers a deficiency of Thiamine. It is the probable alternative of Thiamine which can fulfill the deficiency of Thiamine in the human body.
Benfotiamine as a Thiamine Derivative:
It is the best available alternative of Thiamine and in fact, it works better than Thiamine. It penetrates through cell membranes and helps to protect the AGE-vulnerable tissues. These tissues get harmed by either the glucose-lipid reaction or by the glucose-protein reaction. It helps to protect the human nervous systems and other active organs.
The composition of Benfotiamine:
It is composed of a synthetics-acyl derivative of vitamin B-1 or thiamine. The proper name of Benfotiamine is S-benzoylthiamine O-monophosphate, which is a very effective amphiphilic S-acyl thiamine derivative. This lipid soluble Thiamine has a much more bioavailability than the natural Thiamine. Benfotiamine is converted to Thiamine after the oral ingestion. Then Benfotiamine is considered as one type of prodrug for natural vitamin B-1 or Thiamine. Benfotiamine is fat soluble or hydrophobic. The structure of Benfotiamine is stable until it is dephosphorylated. Due to dephosphorylating, it degrades to Thiamin.
- Don’t confuse it with Allithiamine which is a natural occurring Thiamine derivative as Allithiamine has a completely different pharmacological background than this product.
- Don’t confuse this product with Sulbutiamine which is composed of two Thiamin molecules. Sulbutiamine results in very different actions.
How does Benfotiamine work?
Thsi product is practically insoluble in normal water. It is capable to prevent the progressions of various diabetic complications in diabetic patients. It is capable to increase the tissue levels of Thiamine.
Absorption of Benfotiamine:
Surprisingly, it gets easily absorbed in human metabolism and the rate of its absorption is 5-fold of the absorption rate of Thiamin and 3.7-fold higher than the absorption rate of Thiamin Hydrochloride for the human body. Only by oral dose, the product is absorbed by 40% in the human body. It is capable to enhance the bioavailability and is surely more absorbable than the natural Thiamin in the human body. The absorption is related to another structure of the open thiazole-ring. After absorption, Benfotiamine is phosphorylated to S-benzoylthiamine to enable the passive membrane transport in the human body.
As the product has the better absorption rate than other related structures of Thiamine, it is metabolized easily to free Thiamin molecules. This prevents the increase of serious diabetic related complications in the human body. It increases the tissue levels of thiamine diphosphate. Due to the increase of thiamine diphosphate tissue levels, Benfotiamine enhances the glucose metabolism activities to maintain a normal blood sugar level. The human brain is very sensitive and highly affected due to the deficiency of thiamine in the human body. When Benfotiamine increases the thiamine phosphate levels in the brain immediately gets the required thiamine after oral administration.
Distribution of Benfotiamine in the body
This product’s ingestion in human body results in the increase in quick serum spikes. The human body gets increases in Thiamin metabolite which is detected in the relatively quick serum spikes. This effect can be observed within one hour of the ingestion of this product in the human body.
After one hour of the oral ingestion of Benfotiamine, the tissue concentrations of Thiamine diphosphate, thiamine monophosphate, and thiamine is elevated and these components can be detected in the kidney or liver within the amount of 100 to 300 mg per kg. Thus it can effectively increase the tissue concentrations of Thiamin just after the oral ingestion.
How blood flow changes after absorption of Benfotiamine
As said previously, it is easily absorbable in the body. Immediately after absorption, it starts to show its effect by changing the blood flow. If a diabetic patient uses 2x50mg Benfotiamine daily for 12 weeks continuously then the person gets improved endothelial-dependent blood flow. The point to be noted is that the changed blood flow is not endothelial independent. This effect of Benfotiamine suggests the ability of it to increase the bioavailability in the human body.
The effects on the process of Glucose Metabolism
After oral ingestion, it gets easily absorbed up to 40% and then it brings its effects on the metabolism process. Benfotiamine, being the substrate of the enzyme named Prostatic Acid phosphatase, brings resinous effect on the metabolism process.
The product is dephosphorylated into the echo-alkaline phosphatase and then it is named as S-benzoylthiamine. This new form of Benfotiamine then passively degrades into another new component named O-benzoylthiamine. This new form of it converts into the powerful and active Thiamin modules. The entire process of thiamin creation after oral ingestion of Benfotiamine is called as the Thio-esterase-dependent mechanism. In this metabolic process, the created active thiamine might degrade to other passive components of thiamine under alkaline conditions. This metabolic process of thiamin in the liver leads to the creation of free benzoic acid.
How Benfotiamine controls the glucose level?
It gets directly involved in the glucose metabolism process of the human body. In some stages of hyperglycemia, the human body requires much energy to maintain its functionality. This influx of energy is directly coupled with the superoxide radical. Benfotiamine increases the production of the required superoxide in the metabolism. It partially inhibits the enzyme named Glyceraldehyde Phosphate Dehydrogenase. This enzyme in human blood is responsible to divert the glucose away from the glycolysis process.
Where does the glucose go then? The glucose leads towards the alternate pathways. The created partial inhibition of the GAPDH compound is responsible for the relative accumulation of the glucose metabolites. This process is prior to that enzyme which is very important for the glycolytic chain.
The product is really helpful and effective to maintain a normal glucose sugar level. This is possible due to the creation of a transketolase enzyme in human glucose metabolism process. It is capable to increase its activities in the human body at the low-active enzyme named transketolase. In this lower active stage, the state of hyperglycemia is capable to reduce the extra sugar which was built up in the blood. Thus Benfotiamine affects the glucose metabolites process. So, when the body faces excessive concentrations of sugar in the blood, it directly contributes to the pathology to reduce sugar level to normal.
The substance is effective to control the diabetic microvasculature damage and the damages include nephropathy and neuropathy. It carries several direct anti-oxidant properties. These properties are responsible to attenuate the hyperglycemia condition by inducing the oxidation damage. Hyperglycemia is the condition where the normal blood sugar level in a human body increases to a great extent. Benfotiamine effectively controls the raised blood sugar level by reducing it to the normal level.
The substance is derived from thiamine. By the consumption of Benfotiamine, the thiamine level in human blood rises. The raised thiamine level helps to protect the human body from various serious health conditions which might occur due to the lower thiamine levels in the body.
Natural Thiamine is found in various food items such as eggs, fish, meat and fortified grains. Those who avoid protein intake might face lower thiamine level. So, it’s really very important to include items rich in thiamine in the daily diet.
The tablets are available in the market at low price. The tablets are primarily marketed as the antioxidant dietary supplements. While in some countries, the Benfotiamine tablets are marketed as a drug. The tablets are used to treat the diabetic neuropathy.
Each tablet is 150 mg. In one file, you will get almost 100 numbers of tablets. You can consume two tablets on a regular basis for two weeks to get the best results. The best benefits of It can only be achieved if the patient takes regular dosage of 150 to 1,000 mg. per day. The patient must continue this dosage for the duration of two weeks to get the most effective results. As Benfotiamine is one form of the thiamine it is very safe to consume. The side effects of Benfotiamine are negligible if it is consumed by maintaining proper dosage. It is highly safe. It does not contain any toxic substance or drug.
Pros to use Benfotiamine:
As it is one compound of Thiamine, it is very secure to use. People might have it on a regular basis to maintain proper thiamin levels in their body. Those who eat carbohydrate-rich foods more that protein might have to lack in proper thiamin level. So, to have regular Benfotiamine tablets is a must for them. The regular dosage of Benfotiamine brings some positive effects in the human body. Those how are involved in strenuous exercising on a regular basis might need more thiamine on a daily basis. Hyperthyroidism is responsible to increase the demand for thiamine in the body. Here are some pros of using Benfotiamine tablets on a regular basis.
- Controls blood sugar level
The tablets are capable to control higher blood sugar levels effectively. This is probably good news for all the diabetic patients. Those people, who are suffering from the type 2 diabetics, can have a regular dosage of Benfotiamine tablets to maintain their sugar level. Benfotiamine protects the body from the oxidation stress, which occurs due to the high level of sugar in the blood. According to some researchers, the diabetic patients who took Benfotiamine tablets for 12 weeks are resulting to have balanced blood sugar levels.
- Use in Diabetic Neuropathy
The tablets might be useful to treat the diabetic neuropathy. It is the condition which happened due to the damage to the nervous system. Diabetic Neuropathy is related to the high blood sugar level and it can be cured by Benfotiamine.
- To aid Alzheimer’s Disease
The tablets can be used to treat the Alzheimer’s disease. For this, the patients might need to continue the dosage of Benfotiamine for minimum 18 months on a regular basis.
- Great Antioxidant
The tablets work as great antioxidants for the body. They have the highest antioxidant capacity to prevent the DNA damage. The patient needs to take Benfotiamine tablets on a regular basis for at least 18 months to bet the best benefits.
- Several health benefits of the substance
Other than the above-mentioned benefits of the substance there are various health benefits of it. Due to low thiamine levels, the individual might face several health problems. Benfotiamine with higher bioavailability offers great health benefits to the body. By increasing the thiamine levels in the body, it works as a natural cure for anxiety, depression, back pain, diabetes, neuropathy, and thyroid disease. It offers an enhanced exercise performance by boosting the energy level. It improves the brain’s functionality by lowering the lactic acid level.
Cons using Benfotiamine
As mentioned earlier, this product offers various health benefits. But, with some pros, there must be some consequences. Surprisingly; it brings very lesser side effects to the body. Although many people are not concerned about the safety levels of having Benfotiamine tablets they must know it is they are having it for a long time.
Those who have the tablets for long times might face some side effects, including upset stomach, weight gain, nausea, hair loss, dizziness, and a serious decrease in blood pressure. Those people who are sensitive to sulfur must avoid having this product on a regular basis. Though nobody can surely say about the right and effective dosage of Benfotiamine it can be considered as a supplement of natural thiamin in the body. One must consult with the Benfotiamine provider before taking it.