BH4 Review 2018-Benefits & Side Effects (Updated July 2019)

What is BH4?

Bh4 or a Tetrahydrobiopterin is a naturally occurring substance that is highly essential for many body processes. It helps in maintaining our brain, heart, digestive, and reproductive health and keep so many disorders. However, a lack of BH4 in our body has been shown to adversely affect the production of nitric oxide and the circulation of blood flow that may lead to circulatory diseases.


In a case like this, one can take BH4 supplements to make up for lack of production and keep their body fit. For those who are into bodybuilding and strength training, taking this supplement will also be a boon due to its performance enhancing properties that are rather unique.

In this review, we are going to talk about all that you need to know about BH4 and how it can make you excel in workouts and get the desired physique you always wanted. But first, let’s take a look at what this compound is all about.

What does BH4 do?

Tetrahydrobiopterin (BH4) is also known as sapropterin, and it plays a key role in numerous physiological processes in the human body. It is involved in maintaining the health of our heart, form the neurotransmitters, reduce endothelial dysfunction, develop an immune response, and decrease sensitivity to pain.

The substance is also essential for activation of several enzymes, which includes the ones responsible for host defense and a neurotransmitter synthesis. In the context of bodybuilding, this chemical helps in the biosynthesis of neurotransmitters including, serotonin, dopamine, melatonin, epinephrine, norepinephrine, and obviously it in the production of nitric oxide.

The huge amount of evidence suggests that lack of BH4 bioavailability can lead to underdevelopment of nitric oxide-mediated microvascular functions. In simple terms, it means a lack of this chemical in our body can lead to a variety of life-threatening conditions such as hypertension, diabetes, hypercholesterolemia, aging, and atherosclerosis.

Apart from the diseases mentioned above, Tetrahydrobiopterin has also been found to have an effect on clinical trials of ADHD, autism, endothelial dysfunction, hypertension, and chronic kidney disease. So, to sum it up, it wouldn’t be wrong to say that this chemical has its very own significance in not only bodybuilding but also in maintaining overall health.

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BH4 and fitness: How are they related?

Since this substance has been proven to be a booster for neurotransmitters, consuming this supplement can lead to advanced neurotransmission. This consequently will result in more energy and motivation before heading to work out.

The two most crucial neurotransmitters that combat pre-workout fatigue are dopamine and serotonin. While serotonin is usually associated with drowsiness and sleep, and dopamine has a direct impact on influencing one’s motivation. If the serotonin to dopamine ratio is uneven or too high, your body will be in a state of lethargy and work out will become harder.

On the other hand, if the level of dopamine is more than the level of serotonin, the function of your central nervous system will improve and along with that will improve the performance of your exercises. These are just facts that the bodybuilding community has come to accept over time.

The researchers showed that the precursor to dopamine, tyrosine, can be an effective performance booster that can potentially increase the length of a workout session by 16%. Not only does tyrosine help pump out more sets and repetitions at the gym, but also improves our body’s tolerance for exercise, making you less fatigued even after an intense session.

Adrenaline is a hormone that supports our “fight or flight” response in our body, and a shot of adrenaline functions as a pure performance enhancer. BH4 also boasts adrenaline, which in turns increases the levels of fatty acids and glucose in the blood, providing our muscle cells with the required level of energy to tackle heavy workouts.

However, since we’re on the topic of bodybuilding and physical training, it’s important to keep in mind that BH4 itself may or may not be enough to give you the desired results. This is why many supplements focus their efforts on maintaining a steady level of this chemical rather than boosting it to a high enough level that might become intolerable.

Deficiency and Causes

This condition changes the levels of several substances within the body. Phenylalanine is a building block of proteins (an amino acid) that is obtained through the dietary plan. It is located in certain artificial sweeteners and in foods that contain protein. Elevated rates of phenylalanine are found from early infancy in people with tetrahydrobiopterin deficiency that is untreated.

This state also changes the levels of substances called neurotransmitters, which transmit signals between nerve cells in the mind.

Infants with tetrahydrobiopterin deficiency seem normal at birth, but medical problems which range from mild to severe become evident over time. Symptoms and signs of the condition can include progressive problems with development, intellectual disability, movement disorders, difficulty swallowing, seizures, behavioral issues, and an inability to control body temperature.

Tetrahydrobiopterin deficiency might result from mutations in one of several genes, including GCH1, PCBD1, PTS, and QDPR. These genes provide instructions for making enzymes that help recycle and create tetrahydrobiopterin. The procedure is typically helped several amino acids, including phenylalanine by tetrahydrobiopterin.

It is additionally involved in the creation of neurotransmitters.

No tetrahydrobiopterin or little can be obtained to assist procedure phenylalanine if among the enzymes fails to operate correctly as a result of a gene mutation. As a result, phenylalanine can build right up in the blood and other tissues. Brain damage can be caused by excessive amounts of this substance because nerve cells in the brain are particularly sensitive to phenylalanine levels.

These abnormalities underlie the intellectual disability along with other characteristic features of the situation.

Other benefits of a BH4 based supplement

  • BH4 prevents heart failure

Nitric oxide synthases (NOS) needs BH4 for the production of nitric oxide. NOS creates superoxide instead of NO, which causes endothelial dysfunction and increases oxidative stress when there is low BH4 concentration.

Oxidative stress can contribute to numerous complications, for example, cardiovascular disease, high cholesterol, diabetes, high blood pressure, and stroke. Supplementation with BH4 prevents these disorders and may restore BH4 concentrations.

The heart conditions could be restored by infusion of BH4 in patients with congestive heart failure, type II diabetes, and high cholesterol and heart problems.

A single oral therapeutic dose of a synthetic BH4 enhanced skin vasodilation that was reflex during entire body heat stress by augmenting NO-mediated dilation.

Blood flow restriction (ischemia) fell cardiac BH4 content by 85, 95, or 97% after 30, 45, or 60 minutes of ischemia, respectively. Paralleling the decreases in BH4, reductions of eNOS activity were seen of 92%, 86, or 58, and NOS-derived superoxide production was considerably raised.

Therefore, BH4 depletion contributes to postischemic eNOS dysfunction, and BH4 treatment is effective in partial restoration of endothelium-dependent coronary flow. Supplementation of BH4 may thus be an important therapeutic method of reverse endothelial dysfunction in postischemic tissues.

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  • Treats depression

Depression is related to an inflammatory response in addition to activation of the anti-inflammatory reflex system. It is also accompanied by nitrosative and oxidative stress.

Elevated levels of inflammation and oxidative damage can later result in a depletion of tetrahydrobiopterin amounts.

The depletion of BH4 reduces the synthesis of neurotransmitters like serotonin, melatonin, dopamine, norepinephrine, and epinephrine. These compounds are essential for controlling daily body functions including sleep cycle, mood, recollection, and desire.

Loss of BH4 might describe some of the indications of depression. Then it may be a powerful treatment for depression if BH4 levels improved.

  • Treats Diabetes

Diabetes is distinguished by glucose intolerance and insulin resistance, which is often due to endothelial nitric oxide synthase (eNOS) dysfunction. Gastroparesis can be also caused by diabetes, and its own symptoms include vomiting, nausea, and pain.

BH4 keeps it and helps control eNOS activity. Administrations of BH4 in mice lead to insulin resistance and less glucose intolerance; it’s potential to greatly help relieve symptoms of diabetes.

A really effective pre-workout supplement is one that enhances muscular endurance for extended intensity throughout your fitness regimen. Supplements loaded together with the amino acid beta-alanine, which includes many positive effects on health and workout performance.

Beta-alanine reduces the acidity in muscles and works within muscle cells to buffer the negative effects of lactic acid on exercise capacity. That beta alanine is a vital element for improved muscle endurance during workouts.

  • Enhanced Blood Flow and Stamina

The entire body to relax the muscles of the arterial walls, opening up the arteries and raising blood flow is triggered by the presence of citrulline. This results in increased stamina, thanks to oxygen and essential nutrients being pumped into hardworking muscles.

Watermelon, beetroot and grape skin extracts are also there in an efficient supplement. These natural compounds have been shown to powerfully stimulate the generation of nitric oxide for increased vasodilation and better muscle performance.

  • Potassium and Magnesium Boost Circulation

Potassium and magnesium citrate are strong compounds having a quantifiable effect on circulation. These compounds enhance vasodilation, lowering blood pressure for a workout that is wholesome and improving blood circulation. The addition of citrate upgrades exercises operation for maximum power.

BH4 is a compound that boosts the production of nitric oxide, improving blood flow to the muscles. A little amount of this stuff in the body contribute to circulatory disease and is able to adversely affect the circulation. As a nutritional supplement has not proven to be an effective treatment taking this product, however, improve nitric oxide levels and consumption of folic acid was shown to raise substance generation, rendering it an ideal addition to a supplement.

  • Citrulline Improves Exercise Performance

Exercise-induced muscle fatigue is a serious dilemma for absolutely any dedicated bodybuilder. Among the key contributing factors to exercise-induced muscle fatigue are lactic acid within the muscles and the accumulation of ammonia.

Ammonia is a byproduct of intense muscle contractions, which can quickly build up and cause fatigue.

  • Improve Muscle Strength

To be really effective, any pre-workout supplement has to improve muscle strength and power output. A BH4 based supplement is loaded with all the most effective muscle-building and performance-enhancing compounds on the market nowadays.

Creatine is among typically the most popular and effective bodybuilding supplements. Many studies have clearly demonstrated that creatine can be used to enhance muscle mass thanks to its ability to invert the depletion of energy in the muscle and to store energy.


  • Enhanced Fluid Balance Leads To Greater Strength Increases

Maintaining cell volume and fluid balance throughout a work out is crucial when it comes to combating dehydration. Betaine is naturally found in several foods like spinach, whole grains, and shellfish. Adding it to our formula brings your muscles are directed to by the positive effects of betaine.

In addition to keeping your cells hydrated, package anaerobic power into your moves, betaine is demonstrated to improve muscle protein synthesis and reduce abdominal fat.

Leucine is a strong muscle booster that results in increased muscle development when used after resistance training. However, when taken pre-workout, leucine can, in fact, impair muscle performance and reduce the energy readily available for muscle movement.

Use ROS Exposure For Greater Muscle Growth And Healing

Intense weightlifting puts pressure on causing muscle damage muscle cells and also the requirement for healing and muscle regeneration. The evidence is now emerging which indicates that reactive oxygen species (ROS) that are generated over the course of a work out can aid in the recovery process. ROS are chemically reactive molecules that have oxygen, as well as their presence can assist in muscle regeneration.

Is this product worth trying out?

Yes! A supplement based on BH4 should not only give you additional physical and mental capacity to handle heavier weights at the gym, but also provide excellent overall health condition to sustain for the long term. After all, the biggest achievements we make happen to be the ones that take place slow and steady.

This is why it’s important that you do not give up on using the supplement and tried out at least for 3 to 6 months before expecting to see any results. You’ll be surprised to find out how much you’ve improved not only in physical gains but also in other aspects of your life. It’s now time to try out this product and see for yourself.

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3 thoughts on “BH4 Review 2018-Benefits & Side Effects (Updated July 2019)”

  1. Would like to purchase BH4. “Unable to load page” is all I receive upon clicking on “buy here”.
    Could u assist?

    • Hi Tracy,

      Our partner’s website was down due to maintenance reasons. It’s back operational so you should be able to access their product page
      and buy it.



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