Pramiracetam Review 2018 -Pro’s & Con’s (Updated July 2019)

What is Pramiracetam?

Have you heard of the term “Smart Drugs”? Well, I hope, if not, then you must be pretty excited to know about it. The name Nootropics, they are a category of chemicals that are known as the “Smart Drugs,” These drugs are proven to be advantageous and referred as to enhance the memory, intelligence and cognitive part of the brain. They are sometimes used as supplements as well as therapeutic when it comes to treating certain diseases. Pramiracetam is known to be one of the most interesting nootropics that are available. It focuses and evens every sensory perception that is available. This is a drug which is widely being used by students, writer and mostly somebody who is eager to maximize their mental abilities. In other words, Pramiracetam is getting a wide recognition by the new crowd as it recovers the health of the human brain.



Before trying this magic drug called Pramiracetam, isn’t it is a good idea to gain a little more knowledge about how the drug optimizes our brain performance only by increasing the activity of certain neurotransmitters? Isn’t it smart?

Other Names

Pramiracetam is alternatively known as CI-879 or the drug’s most well-known brand name goes by, Pramistar.

The mechanism of this drug is still not well known, but it appears to alter ECG activity in all the rates that were tested (both young and old). It is similar to piracetam and another racetam. Its mechanisms are dependent on the adrenal glands and some peripheral effects that occur, but beyond that, the mechanisms have not yet further been illuminated.

Pramiracetam is one of a kind of racetam molecule. In relative to other racetam drugs, Pramiracetam is not that well researched to date but does appear to have few human pieces of evidence. It was synthesized from piracetam where it is further modified and has more anti-amnesiac behaviors as seen in mice.

It is most effective when it’s taken acutely (1-2 hours) before cognitive testing, and studies have shown that it is working on the memory but do not produce many effects.

Benefits of Pramiracetam 

Pramiracetam hikes the performance of the brain, especially the formation and retrieval of memory. It also provides a cognitive improvement of the brain.

It mostly creates a distinct kind of feeling and one can focus along with an emotional state. It is mainly compared to Ritalin. Some of the most universally-recognized benefits of Pramiracetam are mentioned below:

    • Memory improvement – just because it helps in stimulating the hippocampus present in our brain, so that is mainly responsible for the formation of new memories, Pramiracetam is said to be a very powerful memory enhancer. Most users report compelling improvement in their memory formation and recalling memory speed, an idea that has been authenticated by animal studies.
    • Learning Capacity that is well expanded– Based on different users report that Pramiracetam makes it faster, easier, and more enjoyable to read or learn.
    • Mentally Alert and Clarity – Consumers of Pramiracetam reviewed that taking the supplement helps those with strong feelings of alertness, the formation of new ideas, etc.
    • Social Fluency – it is reported that Pramiracetam is helping people to become more social. It makes them confident to completely take part in social events. Thus it helps in increasing overall brain function.
    • Improved Sensory Perception – Enhanced sensory perceptions have been reported by the consumers, including deepen and richer sound and clearer and more intense visual perception with excellent color contrast.
    • Memory Reconstruction – In clinical examination stages by the medical teams, Pramiracetam has been evidently found to be effective for memory loss treatment and other subjective problems caused by brain injuries and other brain dysfunctions. It has been tested in the US as a possible treatment of memory loss related to Alzheimer’s disease and other neurological disorders. One study has even shown it to be capable of reversing chemically induced amnesia in healthy volunteers from 18-65 years of age.
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How does it work?

The drug Pramiracetam helps the neurotransmitters to release. Neurotransmitters are brain chemicals that transmit signals from one nerve cell to another. Pramiracetam functions in a different mechanism than the neurotransmitters. It makes the brain active in many other possible ways.

Pramiracetam is said to be fat soluble, which explains that it is absorbed into the blood via fatty acids, rather than being soluble in water. It finds its peak concentrations and maximum possibilities very fast, generally within 25-30 minutes, and it has a moderately long half-life of about 4-6 hours.

Racetams usually work on stimulating the neurotransmitting receptor areas that are present in the brain. But Pramiracetam doesn’t directly result in changes in the neurochemical levels here. It helps in expanding the production and release of specific neurotransmitters.

We know that Choline is a messenger of acetylcholine. It is a neurotransmitter that helps in boosting learning speed, memory, and concentration of a person.

By Choline uptake, Pramiracetam indirectly modulates the release of acetylcholine and stimulates increased activity in the hippocampus of the brain which boosts the parts of the brain. Because this part of the brain is essential for the functioning of the memory, the general stimulation that Pramiracetam creates can improve both the formation of new memories and the retention of reference or long-term memories available. The increased activity in the hippocampus also increases the cerebral blood flow, which reinforces alertness and improves cognitive abilities in general.

Pramiracetam may have various mechanisms of action as well. Researchers have hypothesized that in addition to its effect on the brain, the drug acts in peripheral sites outside the brain that rely completely on the adrenal glands.

Unlike many other racetam class nootropics, Pramiracetam does not appear to actively alter either a complete wakefulness or emotional states. This can be duly explained by pramiracetam’s limited influence on the production and release of the so-called neurotransmitters of the brain that have the greatest effect on mood and anxiety levels such as serotonin, GABA, and dopamine.


The nootropics is well tolerated even at high dosages in terms of reports. The individual reactions may vary and it’s important for each user to find their own optimal dosage to maximize the benefits of the drug. Due to the lack of satisfactory scientific studies and reports, recommendations on the most effective daily dose vary noticeably.

While there are very few unfortunate and detrimental side effects associated with this drug, it is always wise to start with the lowest effective dose and increase the dose gradually as needed. One extraordinary aspect of consuming the powder form of Pramiracetam is that it has a very stinging flavor that most people find extremely unpleasant. Many people either make their own capsules and the rest purchase the capsule form of the nootropics drug that is available in the market.

But still, it is difficult for users to make their own tablet or capsule as per dosage quantity. The powder is full of fat rather than soluble in water which leads to the users in having difficulty in mixing the powder with water. It floats on the surface of the water rather than dissolving in it. Some users mix a small amount of oil along with the Pramiracetam powder which enhances the absorption quality.

Of the numerous studies that have been done on testing the effectiveness of Pramiracetam, it was concluded that a total daily intake of 1200 mg was optimal, divided into two or three doses per day. This is likely a good starting point and on an individual level should be adjusted to find what works best as the dosage varies from person to person.


Pramiracetam works on its own and is well supported, but one of the most interesting aspects of Pramiracetam is that it appears to be a powerful leader for other nootropics, increasing their effectiveness. It is an effective leader with respect to another racetam, making it a natural addition to most nootropics stacks.

Because Pramiracetam has such dominant effects, it is advisable to use it on its own for a trial period prescribed before combining it with other nootropics. Bundling Pramiracetam with energy up gradation tablet like adrafinil or oxiracetam can intensify the mental alertness and extend it over a longer period.Pramiracetam can be equipped with a powerful anti-anxiety agent. Aniracetam is mostly preferred and it can lead users to increase their focus and concentration. There is also improvement of mood and anxiety. Some users say this stack promotes social fluency and improves their outgoing nature and performance ability.Sometimes by adding a choline supplement to a Pramiracetam stack has said to have multiple benefits. It not only enhances the Pramiracetam’s effects but it can also prevent headaches, which are the most commonly reported side effect of this so-called nootropics drug.

Side effects of Pramiracetam

Pramiracetam is usually well permitted even at high dosages, and very few adverse side effects have been documented throughout by the reports. The most common reported side effect is a headache, which can usually be prevented by taking it with a choline supplement as mentioned earlier.

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Less common side effects include gastrointestinal distress and feelings of nervousness or agitation, anxiety is generally associated with high dosage and can, therefore, be avoided by reducing dosage.Pramiracetam is non-addictive, and no significant adverse effects of long-term use have been documented. However, evidence has been found that this nootropics drug or supplement may promote better brain health and also to some extent restore the aging of our brain.

Where to buy Pramiracetam?

Pramiracetam is usually found in retails and medical stores and is not at all hard to find. It is available from specialty online stores that sell nootropics. It is very important to stick to the trusted vendors. Many online stores have their products tested by 3rd party laboratories which ensure that your product is 100% pure and safe to consume.

As we have discussed in other sections of this article that Pramiracetam is an effective and researched nootropic drug. It is advised to make sure to buy Pramiracetam powder only in the last / worst case scenario as it does not dissolve in any liquid making it difficult to consume. For every other Pramiracetam purchase, ensure purchasing capsules is recommended to purchase Pramiracetam from the sellers who shares the ingredients quality as a knowledge update for customers.


To some extent and according to the researchers and reports, Pramiracetam is still fairly unknown, and all of its mechanisms are not yet understood clearly, so let’s look after few other options if Pramiracetam is not available. Other Racetams includes the following:

  • Racetam

The Racetam family has other offerings that confer a range of effects. If you’re looking for something else that will sharpen your mind, you might try Piracetam. It has a milder effect (perhaps ten times less potent than Pramiracetam), so it’s a good option if you’d prefer to start small and work your way up to big league supplementation. Aniracetam might be a suitable choice if you want a boost in mental energy and sociability. Reports of Aniracetam state that it can increase your social fluidity, making the user more energetic and building the will to engage in conversation and more capable when doing so.

  • Noopept

If there is a need for a person for the supreme mental boost, Noopept is probably what is needed. It’s supposedly ‘1000 times more powerful than Piracetam’, requiring a much lower dose to achieve an effect, and demonstrating much more potent benefits in addition to psych stimulatory and anxiolytic effects as well. Users, who have been consuming Noopept and has done a limited research about the claims believe that it can work wonders for the brain. As a brain supplement, Noopept can act great as a nootropic drug in its best form that is available in the market.

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  • Phenibut

Phenibut is a known GABA derived nootropic with mood-altering properties. It is used to enhance general well-being, curb anxiety, combat depression, and improve cognitive function of the users as given in reports. There’s a potential for overuse with Phenibut, as there might be possibilities to quickly build up a tolerance to its effects. Used sparingly, though, it does promise to work as a brain drug and might make a handy addition to your stock.


Thus we can finally conclude that Pramiracetam is a very powerful nootropic drug that is relatively new to many users but is rapidly growing in popularity throughout the various parts of the world.

As it’s more complicated to synthesize it’s higher in price than other racetams; some users find the cost too high. Though, the high potency of the supplement also means that lower dosages are needed. Users also have mixed Pramiracetam to the Ritalin-like emotional blunting effect of the supplement. For some people, it creates a welcome neutrality and relief from social anxiety, while others say it makes them feel disconnected.

Pramiracetam is widely accepted as an excellent nootropic, measurably improving memory formation and retention, learning speed and mental clarity in general, awareness, and focus. It’s generally considered to be a valuable addition to other nootropic stacks, in many cases increasing both the potency of the other stacked supplements and the duration of their effects that are available in the market. Pramiracetam’s are mostly secure, dominant, brisk and relatively long-lasting. It has been found to be a valuable nootropic supplement for students, writers, researchers, or anyone who wants better memory, faster recall, and greater mental focus, clarity, and speed of thought.

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